Summary
The study utilized C-Pittsburgh Compound B (PiB) and F-Flortaucipir (AV1451) PET imaging acquired from either Siemens/CTI or GE scanners. PiB PET involved a bolus injection followed by a 60-minute dynamic acquisition, while AV1451 PET followed a similar injection protocol with presumably 5-minute frames. PET data underwent reconstruction and were evaluated for motion artifacts. PiB and AV1451 dates were collected simultaneously for most participants. MRI was performed on a 3T Tim Trio (Siemens) and processed with FreeSurfer for ROI parcellation.
FHS PET Processing Details
A description of the PET data acquisition and pre-processing steps was adapted from Sanchez et al and Gonzales et al:
- PiB PET data were expressed as the distribution volume ratio (DVR) by Logan (40-60 min) and AV1451 PET data were expressed as the standardized uptake value ratio (SUVR; time frame to be determined); both metrics use cerebellar gray as the reference region and do not use partial volume correction. Each participant’s PiB DVR and AV1451 SUVR data were coregistered to their closest MRI scan and MRI data along with the aparc+aseg FreeSurfer labels were coregistered to PET space. PiB DVR and AV1451 SUVR values were extracted from each aparc+aseg region and volume-weighted DVR and SUVR values were calculated for each bilateral region.