Figure 1

Figure 2

Figure 1-2. The age distribution of FHS participants at each health exam (core exam) across all six cohorts: Original Cohort (Gen I, n = 5209), Offspring Cohort (Gen II, n = 5124), Generation 3 Cohort (Gen III, n = 4095), New Offspring Spouse Cohort (NOS, n = 103), Omni 1 Cohort (n = 506), and Omni 2 Cohort (n = 410). The numbers in Figure 2 represent the health exam order of each FHS cohort. Note: Unlike the other three generations, Omni 1 and Omni 2 were independent and have no generational relations.

Cohort	Number	Exam Cycles	Description
Gen I	5209	32	Also known as the Original cohort Only cohort with each exam/interview cycle 2 years apart No remaining survivors
Gen II	5214	10	Also known as the Offspring cohort They are generally the offspring of the Gen I participants Each exam/interview cycle 4 – 5 years apart
Gen III	4095	3	They are generally the offspring of the Gen II participants (i.e. grandchildren of Gen I) Each exam/interview cycle 4 – 5 years apart
NOS	103	3	They are generally the spouses of the Gen II participants Each exam/interview cycle 4 – 5 years apart Follows the exam schedule of Gen III
Omni I	506	4	First multiracial cohort Each exam/interview cycle 4 – 5 years apart Exam Cycle 1 was in sync with Gen II’s Exam Cycle 6
Omni II	410	3	Second multiracial cohort Unrelated with Omni I Each exam/interview cycle 4 – 5 years apart

FHS Cohort Health Exam Dates and Age Ranges (Oct 2023)

Table 1. Original Cohort (idtype=0)

Exam #	Exam Date Range	Age Range	Mean Age	Total # of Participants
1	1948-1953	28-74	44	5209
2	1950-1955	31-65	46	4792
3	1952-1956	32-67	48	4416
4	1954-1958	34-69	50	4541
5	1956-1960	37-70	52	4421
6	1958-1963	38-72	54	4259
7	1960-1964	40-74	55	4191
8	1962-1966	42-76	57	4030
9	1964-1968	44-78	59	3833
10	1966-1970	46-80	61	3595
11	1968-1971	49-81	62	2955
12	1971-1974	50-83	64	3261
13	1972-1976	53-85	66	3133
14	1975-1978	55-88	68	2871
15	1977-1979	57-89	69	2632
16	1979-1982	59-91	70	2351
17	1981-1984	61-93	72	2179
18	1983-1985	63-94	74	1825
19	1985-1988	65-96	75	1541
20	1986-1990	67-97	77	1401
21	1988-1992	69-99	79	1319
22	1990-1994	72-101	80	1166
23	1992-1996	73-101	81	1026
24	1995-1998	76-103	83	831
25	1997-1999	78-104	84	703
26	1999-2001	79-103	86	558
27	2002-2003	82-104	87	414
28	2004-2005	84-104	89	303
29	2006-2007	85-102	91	218
30	2008-2010	88-102	92	141
31	2010-2011	90-99	92	91
32	2012-2014	93-106	96	40

Table 2. Generation 2 Cohort (idtype =1)

Exam #	Exam Date Range	Age Range	Mean Age	Total # of Participants
1	1971-1975	5-70	36	5124
2	1979-1983	17-77	44	3863
3	1983-1987	18-77	48	3873
4	1987-1991	22-81	52	4019
5	1991-1995	26-84	55	3799
6	1995-1998	29-86	59	3532
7	1998-2001	33-90	62	3539
8	2005-2008	40-93	67	3021
9	2011-2014	46-98	71	2430
10	2019-2022	55-102	77	1501

Table 3. Generation 3 Cohort (idtype =3)

Exam #	Exam Date Range	Age Range	Mean Age	Total # of Participants
1	2002-2005	19-71	40	4095
2	2008-2011	24-78	47	3411
3	2016-2019	32-84	54	3171

Table 4. New Offspring Spouse Cohort (idtype=2)

Exam #	Exam Date Range	Age Range	Mean Age	Total # of Participants
1	2002-2005	47-85	65	103
2	2008-2011	53-90	70	68
3	2016-2019	60-93	75	56

Table 5. Omni 1 Cohort (idtype=7)

Exam #	Exam Date Range	Age Range	Mean Age	Total # of Participants
1	1994-1998	27-78	52	506
2	1999-2001	33-83	55	405
3	2007-2008	39-89	62	298
4	2011-2014	44-88	66	301
5	2019-2022	52-96	72	197

Table 6. Omni 2 Cohort (idtype=72)

Exam #	Exam Date Range	Age Range	Mean Age	Total # of Participants
1	2003-2005	20-80	43	410
2	2009-2011	25-85	48	321
3	2016-2019	32-89	54	294