- ❤️ Since 1948, the Framingham Heart Study (FHS), under the direction of the National Heart, Lung, and Blood Institute (NHLBI), formerly known as the National Heart Institute, has been committed to identifying the common factors or characteristics that contribute to cardiovascular disease (CVD) over a long period of time in three generations of participants. Since 1971, the Boston University Aram V. Chobanian & Edward Avedisian School of Medicine (BUMC) has served as an NHLBI contractor and academic partner for the study. In 2020, the BUMC received an infrastructure grant from the National Institute on Aging (NIA) to establish the FHS Brain Aging Program (FHS-BAP). Since its inception, the FHS-BAP Data Core has played a crucial role in strengthening the data infrastructure necessary for studying brain aging, cognitive decline, Alzheimer’s disease (AD), and all causes of dementia.
- ☑️ Our strategy for managing and sharing FHS data for AD research covers a wide range of information, including legacy data like demographics, nutrition and life-style risk factors, lab biomarkers, NP assessments, and brain MRI/PET data. We also incorporate new clinical data and digital markers. Upholding FAIR principles, we ensure data integrity and accessibility. Through collaboration with FHS-BAP internal cores, contract staff, and external teams, we facilitate the collection, auditing, and sharing of curated datasets for analysis.
- 🔖 Tsao CW, Vasan RS. Cohort Profile: The Framingham Heart Study (FHS): overview of milestones in cardiovascular epidemiology.Int J Epidemiol. 2015 Dec;44(6):1800-13. doi: 10.1093/ije/dyv337. PMID: 26705418; PMCID: PMC5156338.
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